OC38.01: Screening for Down syndrome using first-trimester combined screening followed by second-trimester ultrasound examination: evaluation of the compliance

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Screening for Down syndrome in the second trimester of pregnancy.

Antenatal screening for fetal anomalies has provided women and their partners with information to make reproductive choices based on the risk of serious chromosomal or structural defects since the 1990s. Alternative tests include first-trimester screening (combined ultrasound and maternal serum markers), second-trimester maternal serum markers and noninvasive cell-free DNA testing. The recent r...

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Role of second-trimester genetic sonography after Down syndrome screening.

OBJECTIVE To estimate the effectiveness of second-trimester genetic sonography in modifying Down syndrome screening test results. METHODS The First and Second Trimester Evaluation of Risk (FASTER) aneuploidy screening trial participants were studied from 13 centers where a 15- to 23-week genetic sonogram was performed in the same center. Midtrimester Down syndrome risks were estimated for fiv...

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First- and second-trimester evaluation of risk for Down syndrome.

OBJECTIVE To investigate the differences in costs and outcomes of Down syndrome screening using data from the First and Second Trimester Evaluation of Risk (FASTER) Trial. METHODS Seven possible screening options for Down syndrome were compared: 1) Triple Screen-maternal serum alpha fetoprotein, estriol, and hCG; 2) Quad-maternal serum alpha fetoprotein, estriol, hCG, and Inhibin A; 3) Combin...

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Second-trimester genetic sonography after first-trimester combined screening for trisomy 21.

OBJECTIVE The purpose of this study was to evaluate the trisomy 21 screening performance of the first-trimester combined test followed by second-trimester genetic sonography. METHODS This retrospective cohort study included all women with singleton pregnancies undergoing combined screening followed by genetic sonography at 17 to 21 weeks from January 1, 2005, to January 31, 2008. Combined tes...

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Nuchal translucency measurement in first trimester Down syndrome screening.

(1) Approximately three in every four fetuses with Down syndrome have increased nuchal translucency (NT), which is a larger than normal build-up of fluid at the back of the neck. (2) The ultrasound measurement of NT between 11 and 14 weeks' gestation, in combination with the mother's age and the levels of placental biochemical markers in her blood, can be used to detect approximately 84% of fet...

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ژورنال

عنوان ژورنال: Ultrasound in Obstetrics and Gynecology

سال: 2005

ISSN: 0960-7692

DOI: 10.1002/uog.2231